Friday, April 27, 2012

Waters XEVO TQ | 2010 | Used Triple Quad LC/MS

Product Description: Xevo TQ from Waters is designed for quantitative UPLC/MS/MS applications, so you can confidently quantify and confirm trace components in the most complex of samples. What's more, you can do this with unparalleled ease, speed, and accuracy.


Xevo TQ features ScanWave collision cell technology to provide enhanced spectral LC/MS/MS data acquisition capabilities. Unlike conventional tandem quadrupole mass spectrometers, the Xevo TQ is designed to provide not only the very best quantitative data, but also superior spectral MS/MS information. You benefit from more versatility in a single instrument platform, which is adaptable to a wide variety of different UPLC/MS/MS applications both quantitative and qualitative: bioanalysis, ADME screening, food safety, environmental monitoring, forensic, and more.

Features:

Engineered Simplicity - the combination of highest performance with system versatility and simplicity of  operation
ScanWave - innovative technology that provides rapid, high quality, UPLC-compatible, MS/MS data
  acquisition
RADAR - an information rich acquisition approach that allows you to collect highly specific quantitative
  data for target compounds while providing the ability to visualize all other components
Versatility - an extensive range of ionization capabilities to service the broadest range of applications
Simplicity of operation - guarantees maximum system performance that is accessible to the broadest 
   range of users

Includes:
• Waters XEVO TQ - 2010 System
• APCI & ESI Source
• Waters Acquity UPLC with Solvent Manager
• Pentium IV Workstation Pre-Loaded w/software
• Vacuum Pump
• All Required Cables
• Manuals
• & More...

For More Details, Please Contact: info@harlowscientific.com




Tuesday, April 17, 2012

Thermo DSQ II Single Quad | 2007 Used GC/MS System


Description - Thermo Scientific DSQ II single quadrupole GC/MS system is an evolutionary product that will change the way you work with GC/MS analysis. The benchtop system takes trace level analysis and moves it forward by providing innovation and performance while ensuring reliable, accurate analytical results. Equipped with the new innovative DuraBrite XL source and DynaMax XR detection system, the DSQ II Series is able to detect smaller amounts of compounds in difficult matrices, translating into less prep time, smaller injections, less sample, more confidence – real productivity. The Thermo Scientific DSQ II Series provides not just an analytical instrument, but a complete laboratory solution including high performance innovative technology, industry-specific reporting software, method development, and customer support. Whether you are in the Environmental, Forensics, Toxicology, Chemical, Petrochemical, Pharmaceutical, or Food and Beverage industry, we offer the perfect partner for innovation, performance, productivity, solutions, and results.




Less Noise = Better DataFor years, the enemy of optimum GC/MS detectivity has been noise. Background noise arises from multiple sources: sample matrix, column bleed, and source-generated noise (e.g. noise created by excited neutrals). Sample cleanup and routine column maintenance can help reduce two sources of noise. The third, neutral noise is more challenging. Many GC/MS systems address the issue by simply background subtracting or “thresholding” out the noise. However, by masking this low level response, critical isotope ions may be lost or compromised and available dynamic range reduced. This can limit both sensitivity and quantitative capability.

Includes -
• Thermo DSQ II Mass Spectrometer (Single Quad)
• Thermo Trace Gas Chromatograph
• Turbo Pump (250L/s)
• Xcalibur Software V.1.4.1 with license agreement
• Library NIST 05 with 163 198 compunds
• GC including FID, SSI, EFC
• Operator's Manual
• All Required Cables
• & More...

For More Information, Please Contact: info@harlowscientific.com




Amersham Biosciences GE Typhoon 8600 | Variable Mode Imager, Scanner



Description - The all-in-one Typhoon 8600 brings multi-color fluorescence, chemiluminecence, chemi-fluorescence, and filmless autoradiography. This robust tool was originally manufactured by Molecular Dynamics a subsidiary of Amersham Pharmacia Biotech, which was then bought out by GE. Laser excited, pixel by pixel fluorescence measurement eliminates fluorescent blooming and provides better resolution than conventional systems. The 8600's two detectors and dual lasers enable the investigator to employ multiple simultaneous colors and choose from a wide range of fluorescent probes.








Specifications -• Scan Modes : Fluorescence, Chemiluminescence, Phosphorimaging
• Scan Resolutions: 200, 100, 50 microns/pixel (50, 100, 200 data points/cm)
• Excitation Lasers: 532nm, 633nm
• Stadard Emission Filters: 555DF20, 580DF30, 610DF30, 670DF30, 526SP, 560LP
• Beamsplitters: 560, 580
• Platen Size: 35cm, 43cm






Includes - Typhoon8600 (dual laser) , Pentium IV Workstation Loaded with Software, 19" LCD Monitor, Operator's Manual, All Required Cables, Service Report and our standard parts & labor warranty.

For More Information, Please Contact: info@harlowscientific.com



Tuesday, April 10, 2012

Fisher Scientific 650D | Gravity Oven/Incubator For Sale




Fisher Scientific Isotemp 650 D Incubator Gravity Convection Oven For Sale


Description - The Fisher Isotemp 650D incubator with gravity flow circulation provides accurate heating for routine laboratory procedures, drying and staining of slides, paraffin embedding, tissue culture work, incubation of antibody tests, microbiological determinations, crystallization studies and more. Incubator is equipped with an internal GFI outlet (120v) to add a shaker, hotplate stirrer, etc… The Fisher 650D has a temperature range of 30°C to 75°C (86°F to 167°F). This 5 cu-ft incubator’s easy to use keypad control with arrow keys to increase or decrease setpoint temperature in 0.1C increments. Over temperature value is automatically set at 3°C above setpoint. PID controller comes with fixed parameters so no tuning is required. Circuit breaker protects incubator from power surges; battery backup. Designed to stack two units! This incubator includes 2 adjustable shelves.


Includes - Fisher 650D, Operator's Guide, Shelves, Power Cord, and Harlow Scientific parts & labor warranty.

For More Information, Please Contact: info@harlowscientific.com




An Immediate Shortage | Lab Business Magazine Article



Lab Business Magazine Featured Article

"An Immediate Shortage"
By: Jason Hagerman

In October 2005, Eastern Health, the largest health authority in Newfoundland and Labrador, suspended testing of tissue samples from breast cancer patients at its St. John’s histology laboratory after it discovered that a patient received the wrong diagnosis as a result of a botched tissue test.

By May 2007, Eastern Health found itself the target of a massive class action lawsuit. The provincial government’s response—a commission led by Justice Margaret Cameron—produced a report that identified failings at every level of the pathology lab, particularly with how the pathologists performed tests. Quality control measures were not enforced. Accountability in the lab was almost non-existent.

The debacle at Eastern Health left many Canadians uneasy and exposed the anemic state of many of Canada’s under-staffed and ill-managed pathology labs.

Too Few Staff:
The Cameron Report highlighted the central failing of the Eastern Health lab—the lack of competent laboratory staff.

The shortage of lab workers isn’t particular to Newfoundland and Labrador.

“Some provinces experience less of a shortage than others and labs that are close to a university or affiliated with one tend to be better staffed, but there is still a relative shortage in all of Canada,” says Dr. Serge Jothy, chief of the Department of Medicine at St. Michael’s Hospital in Toronto.

The department of medicine at St. Mike’s is equal parts pathology, microbiology, hematology, biochemistry and blood bank. It is well equipped, affiliated with the largest university in Canada—and understaffed. The chemistry lab is one person short, as is the hematology lab. Pathology, where Eastern Health caused so much trauma to so many people, is sufficiently staffed, but this is not so common.

“Impending retirements threaten to leave many labs with shortages of qualified laboratory professionals,” says Christine Nielsen, Executive Director of the Canadian Society for Medical Laboratory Science. And pathology labs are in staff level turmoil in particular.

According to the Canadian Association of Pathologists, the shortage demand for pathologists is growing due to a steadily increasing workload. A general increase of the number of cancer specimens due to an aging population and increases in cancer screening means pathologists are stretched thin. Cancer report requirements are increasing in complexity and quality assurance is increasingly critical.

“We are experiencing a relative decrease in pathologists,” says Dr. Laurette Geldenhuys, President of the Canadian Association of Pathologists. “The increase in the number of non-pathologist physicians generating pathology specimens, such as oncologists, is greater than the increase in the number of pathologists.”

CLICK HERE TO READ FULL ARTICLE:

Sanyo MCL-17AC | CO2 Incubator For Sale





Description - Ideal for research and clinical microbiology, the SANYO MCL-17AC CO2 incubator offers a high-performance solution for mainstream cell culture applications in the research and clinical environment where precise control and contamination resistance is critical.

The sterile environment promotes the integrity of samples, valid test results and the safety of laboratory staff. This exclusive SANYO copper stainless steel alloy offers a significant advantage for contamination control. General Features: SANYO inCu saFe copper-alloy-stainless interior, shelves and plenum More useable space with HEPA filters located out of chamber Polyurethane insulation barrier Direct Heat (Air)™ air jacket surrounding chamber allows uniform temperature distribution with no temperature gradients Direct heating elements blanket the chamber Independent bottom heater adjustment allows relative decrease in RH level Door heater prevents condensation on glass inner door Tempered glass inner door allows sample viewing.


Includes - Sanyo MCL-17AC, Shelves, Humidity Pan, Operator's Guide, Service Report, and our standard parts & labor warranty.

For More Information, Please Contact: info@harlowscientific.com



Solving The World's Problems with New Biotechnology | Labroots.com





"Solving The World's Problems with New
Biotechnology"





By: Allele Biotech


The ability to isolate, create, synthesize, or artificially evolve living organisms towards desirable phenotypes may be increasingly important for solving many of the problems the world is facing. Such problems may include creating renewable energy using bio-waste, finding bio-control products that kill food-spoiling fungi organically, or assaying pathogens in the field using synthetic biological detection systems. With the arrival of synthetic biology, it is possible to design and assemble chromosomes, genes and gene pathways, and even whole genomes, according to the J. Craig Venter Institute. That is, if you know which genes or gene pathways you would need to put into the synthetic genome that would lead to the desired traits. So far, most published synthetic biology work involves bringing in transcription factors from a non-host source to set up an artificial network like circadian oscillators, showing that it can be done and it is interesting.




Through the process of evolution biological systems aptly self-engineer favorable traits in order to survive, but these changes require millions of years to manifest. However, there are quicker adaptations to environmental cues, such as developing antibiotic resistance, which can be achieved through a small number of mutations in hundreds or even dozens of generations. The question is how to harness this kind of adaptation for new strains that can be used as products with defined purposes? As a first requirement, you must have an assay for identifying the wanted mutants or method for augmenting their subpopulation, which is not necessarily easy and normally takes some clever designs to establish. Since evolutionary success in nature results from continuous rounds of gene mutagenesis, expression and selection, an evolution in the lab should ideally proceed with continuity. Previously, each round of mutation and selection takes a few days to complete. Recently, Esvelt et al. in David Lius lab at Harvard demonstrated one way of doing in vitro continuous evolution, by creating a lagoon of mixed E. coli and phages. By continuous dilution of the phage population through outflow, those phages that remain in the pool with properties that help them propagate in the host bacteria will have a better chance to regenerate and accumulate mutations towards the design of the assay [1].

Another aspect of natural evolution is that it occurs in a heterogeneous environment separated into niches of subpopulations with uneven stress levels. Although most evolutions with human intervention were conducted in a homologous population under the same stress and selection, a spatially complex environment may speed up evolution. This may not be easy to imagine, but if a mutant acquires some level of resistance to its environmental stress level and has a chance to move to join a population under higher stress, its relative fitness will likely increase. In addition, in a smaller population in the niche under higher stress, the mutant with marginally beneficial properties acquired under lower pressure can take over more quickly. This was demonstrated by Zhang et al. who showed that with a gradient of antibiotics applied to an array of microwells interconnected through tiny channels, new resistant strains can evolve in less than a day. Without the gradient, or separate the interconnected niches into discrete wells, no resistant populations could be obtained [2].

CLICK HERE TO READ FULL ARTICLE:




Thermo Heraeus HeraCell 150 | CO2 Incubator For Sale




Description - The HERAcell 150 provides a safe, stable, precisely-controlled hypoxic or hyperoxic cell culture environment with the proven contamination control and convenience offered by ContraCon. Only the HERAcell 150 gives you precise O2/N2 control with the convenience of a decon routine that does not require the removal and re-fitting of sensors and shelves.


TC or New IR CO2 Sensor OptionChoose the standard thermal conductivity (TC) sensor with accurate gas sensor technology, or select the optional infrared (IR) sensor with exclusive dual-beam technology – the perfect sensor for precise CO2 control in fluctuating temperature and humidity conditions.






The ContraCon 90°CIs an automatic decontamination routine, which decontaminates the entire interior and water reservoir without the need to remove sensors and fittings (in independent tests, ContraConwas proven to completely eliminate mycoplasma).

Includes - HERAcell 150, Contra-Con (self cleaning) copper interior, shelves, HEPA filter, operator's guide, power cord, and our standard parts & labor warranty. (BRAND NEW)






For More Information, Please Contact: info@harlowscientific.com




Forte Bio Octet Red 96 | Label Free SPR Analyzer



Description - ForteBio’s new Octet RED96 system is a multi-functional, label-free, real-time analysis instrument. It is ideal for rapidly measuring concentration of proteins and other biomolecules, measuring kinetics and affinity, and screening protein-protein and protein-small molecule interactions. The Octet RED96 can be used for a wide range of analyses including IgG and other protein titer, bioprocess development, quality analysis, crude antibody screening, epitope binning/mapping, ligand binding assays, small molecule and fragment screening and analysis, elucidating cell signaling mechanisms and infectious disease monitoring. Replace your stodgy HPLC, ELISA and other single-purpose microfluidics instruments for a unique, cutting-edge, protein analysis system that accelerates and simplifies your work.

Key Features:
Large Quantitation Dynamic RangeThe
Octet RED96 system provides an unprecedented dynamic range from ng/mL to mg/mL for quantitation of biomolecules – 25 ng/mL to 2000 µg/mL of human IgG using Protein A biosensors, in 2 minutes.

Versatile Kinetic AnalysisAccurate kinetic analyses of large macromolecules such as IgG to small molecule fragments of 150 Da are possible on the Octet RED96 system.

8-Channel ThroughputThe Octet RED96 system uses disposable biosensors in an 8x12 array in a simple, Dip and Read™ label-free assay format to measure the titer of 96 samples in 30 minutes.

Low Operational CostCombined with biosensor regeneration, Octet RED96's re-racking option provides ultra-low cost per test for direct binding concentration measurements and kinetic analyses.

Concentration AnalysisMeasure concentrations on native proteins and other biomolecules by direct binding from solutions in a 96-well microplate in a simple, one-step, Dip and Read assay. A large dynamic range for direct binding from ng/mL to mg/mL combined with 8-well simultaneous read-out gives you results in 32 minutes for 96 samples. With the newly added biosensor re-racking feature, Octet RED96 extends the number of tests performed with a single biosensor. Run high sensitivity sandwich ELISA and other ligand binding immunoassays on the Octet in just an hour or two! And, assays are hands-free!

Kinetic AnalysisOctet RED96 provides reliable kinetics information including ka, kd and KD for protein-biomolecule interactions all the way down to protein-small molecule interactions. With 8-channel simultaneous detection, the Octet RED96 gives you the power of 8x12 multiplexing to analyze about 960 interactions in one experiment. Perform crude antibody screening and epitope binning and mapping for rapid development of biopharmaceutical drugs, or, screen more than 400 compounds in a small molecule and fragment library in 8 hours. Follow up the screen with accurate kinetic characterization of your drug candidates on the same system.

Includes - ForteBio Octet RED96, Operator's Guide, Data Station, Software, LCD Monitor, All Required Cables, and a one year warranty.


For More Information, Please Contact: info@harlowscientific.com

Perkin Elmer EnVision 2100 | Multilabel Microplate Reader





Description -The Wallac 2100 EnVision is the world’s first multilabel plate reader developed to give optimized performance in every application. Based on a revolutionary modular design, it supports all the application areas that you and your colleagues work with, now or in the future. Modular design also means that when new types of assays come into use, or if your work changes, new modules can be added. Modularity stands for optimal performance with no compromise for each specific application. EnVision won’t keep you waiting. The measurement time for a 1536-well plate is less than one minute (one flash/well).








Key features
-
• Modular design allowing:
- Optimization for specific applications
- The possibility to upgrade later as needs change
• Fast measurement of all plate formats
• Supports all five main non-radiometric technologies with the facility for:
- Kinetic measurements
- Scanning of the well area
• Manual/Robotic loading and plate stackers available
• Windows NT/2000 software supporting:
- Easy connectivity
- Database storage of all results and protocols
• Bar-coded filters and optical modules
• Easy to learn and to use

Technologies -
Time-resolved fluorescence (TRF) (240-850 nm)
• Multiple time window TRF
• Dual emission measurements for Europium and Samarium labels (DELFIA technology)
• Dual emission measurements for LANCE assays
• Ratio measurements Fluorescence intensity (240 - 850 nm)
• Simultaneous dual emission measurements from the top of the plate or below it (two detector
system)
• Ratio measurements Fluorescence polarization (FP) (240-850 nm)
• Simultaneous dual emission measurements (two detector system)
Luminescence
• Simultaneous dual emission measurements (two detector system)
• Glow luminescence measurements Absorbance (240-850nm)
• Ratio measurements

Includes - Perkin Elmer EnVision 2100, Pentium IV Data Station, 19" LCD Monitor, Operator's Guide, All Required Cables and our standard parts & labor warranty.

For More Information, Please Contact: info@harlowscientific.com






Friday, April 6, 2012

Molecular Devices SpectraMax M2 | Multilabel Microplate Reader For Sale

Description - SpectraMax M2 is a dual-monochromator, multi-detection microplate reader with a dual-mode cuvette port and 6-384 microplate reading capability. Detection modalities include absorbance (UV-Vis Abs) and fluorescence intensity (FI) and have optical performance comparable to a top-of-the-line dedicated spectrofluorometer or spectrophotometer. Endpoint, kinetic, spectrum and area-well scanning read types and PathCheck allow homogeneous and heterogeneous microplate assays to be performed in this flexible system. The FI and Abs microplate reader with built-in cuvette port allows easy conversion and optimization of very-low-throughput assays into medium-high-throughput microplate assays. The SpectraMax M2 allows faster, more precise results and reagent savings. In addition, combined absorbance and fluorescence intensity assays can be run by issuing a single read command.

Key Features -
• Dual mode cuvette port
• Robotics compatible
• Multilabel
• Dual monochromators

• Absorbance (UV/Vis Reading)
• Fluorescence (Fl Reading)
• Time Resolved Flourescence (TRF Reading)
• Luminescence Reading

If you would like more information, please contact: info@harlowscientific.com








Waters Alliance 2695 HPLC Video Harlow Scientific





















Click Here To Watch The Waters 2695 Alliance HPLC Harlow Scientific Video

Waters Alliance 2695 | HPLC System w/ 2996 PDA


Description - The Waters 2695 features a large, easy-to-use LCD interface. Scientists can take advantage of the quick autostart and optimize their methods with a simple push of a button. Manage up to 120 industry standard vials with the built in autosampler. This reliable tool is a common work-horse in most analytical and contract labs. Built to meet labs rigorous requirements or routine analysis, this robust instrument is easily found in Pharmaceutical, Food Safety, R&D, Chemistry, Environmental or Quality Control labs. Simplify how you collect data, built-in compliance and validation features. The Empower software is capable of automating method development, archiving methods and customizing data reports. Other features include audit trails with ConnectionsAQT (GxP & 21 CFR Part 11 requirements).

Includes - Waters-2695 separation module, solvent tray, Empowers Pentium IV Data Station, Brand New 17" LCD monitor, 2996 PDA Detector, service/calibration report and Harlow Scientific warranty. Column cooling/heating compartment available for additional cost.

For more information, please contact: info@harlowscientific.com


Thursday, April 5, 2012

BIAcore 3000 | Used SPR Analyzer For Sale




Description - The BIAcore 3000 is a state of the art SPR instrument that measures interactions between biomolecules. The 3000 system answers many basic questions about biomolecular interactions, such as: How fast is the interaction? How strong is the interaction and how specific is the intereaction? SPR works when light is reflected under certain conditions from a conducting film (thin layer of gold) at the interface between two media of different refractive index. In short, if your creating a drug and want to know how quickly it metabolizes this is the system for you.




Key Features
-
• Kinetic Screening and Profiling
• Kinetic Characterization
• Concentration Measurement
• Sample Recovery for MS
• Thermo Dynamic Characterization
• LMW Interaction Analysis

Includes - BIAcore 3000 SPR Analyzer, BIAevaluation 4.1 Pentium IV Workstation, LCD Monitor, Operator's Guide, FULL SERVICE PM, Service Report, All Required Cables, and Harlow Scientific Warranty.

For More Information, Please Contact: info@harlowscientific.com

Beckman Vi-Cell | Used Viability Analyzer For Sale

Description- The Beckman Vi-CELL Cell Viability Analyzers provide an automatic and cost effective means to perform the try-pan blue dye exclusion method. This data is essential to the decision making process for basic tissue culture cell passage and maintaining optimum culture conditions in bioreactors. Cell and tissue culture applications in life science research, including recombinant protein and biopharmaceutical production, require the accuracy, precision and automation available only in the Vi-CELL cell viability analyzer

The Vi-CELL XR automates the widely accepted try-pan blue cell exclusion method. Historically, cell viability determinations were performed manually using a light microscope and hema-cytometer. This technique has major shortcomings due to subjective determination of cell count, as well as manual, time consuming steps. In comparison to the manual technique, the Vi-CELL automatically performs the try-pan blue with video imaging of the flow-through cell. Results are obtained in minutes.

Product Features:· Automation of the standard try-pan blue assay
· % Viability
· Total cell concentration
· Total viable cell concentration
· Mean cell size
· Real time cellular images
· Bioprocess monitoring
· Validated reagents
· Convenient reagent pack

Includes - Pentium IV Data Station Running Viability Software, Keyboard, Mouse & LCD Monitor, Operator's Guide, All Required Cables, Harlow Scientific Warranty.

For More Information, please contact: info@harlowscientific.com

Wednesday, April 4, 2012

Sell Us Your Laboratory Equipment and Surplus Instruments


Harlow Scientific offers our clients a wide range of options for purchasing equipment. Depending on your needs, we can broker, consign, or buy your surplus lab equipment for cash. We also accept trades.

Harlow Scientific specializes in getting customers the most return for high-end capital equipment. If you have a whole lab or just one instrument, we have worldwide contacts and marketing capabilities to convert your equipment into recovered income.

We welcome questions and can provide references.
Please contact Harlow Scientific for a Free Valuation/Assessment for a piece of equipment or an entire laboratory.

If you have lab equipment for sale, please contact us at 888-5-HARLOW or e-mail us.

Agilent G1600AX | Capillary Electrophoresis System



Capillary electrophoresis (CE) with its high efficiency, rapid analysis time and use of minimal sample and reagent volumes. The G1600AX covers a broad range of applications in a wide variety of industries. This 3D CE system includes diode array detection with extended light-path capillaries, automated fraction collection, capillary electro-chromatography (CEC), high sensitive detection cell and fully integrated solutions for CE/MS.





Includes - Agilent G1600AX 3D CE System, G1601A CE Chemstation Pentium IV Data Station, ACER 17" LCD Monitor, Operator's Guide, All Required Cables and Harlow Scientific warranty.

For More Information, please contact info@harlowscientific.com

Sorvall Legend RT | Refrigerated Benchtop Centrifuge

The Sorvall Legend RT is the first refrigerated benchop centrifuge that combines speed and capacity with a wide selection of rotors and adapters available for a max capacity of three liters. User friendly functionality with easy soft touch keypad for one touch control of speed, programming and pre-cooling functions. The Sorvall Legend RT benchtop centrifuge is easily maintained with a brushless motor and comes equipped with SMARTspin imbalance detection system for safe use.The Legend RT is ideally suited for both research and clinical separation needs. This centrifuge easily accommodates blood collection tubes, conical tubes, flasks, and microtubes. Rotor systems designed to handle up to 108 x 5/7 ml blood collection tubes, 28x50 ml conical tubes or 6x250 ml bottles in a single run allowing you to increase your productivity.

Sorvall Legend Includes - 4-Place swinging bucket rotor, buckets, power cord, operator's guide and Harlow Scientific warranty.

For More Information Contact info@harlowscientific.com


Used Laboratory Equipment: Bringing Hand-Me-Downs To Science, Article by Frost Sullivan

Among the plethora of life sciences tools companies, there exists a market for used and refurbished equipment that follows a differant business model and contains unique dynamics compared with new product sales. Never the less, it is a quickly growing market in terms of competition, customers, and revenue. The number of competitors within the market has grown considerably over the past five years, with few barriers to market entry. While the number of used equipment suppliers continues to increase, the rapidly growning number of customers buying used products has compensated for this intensified competition. The ebb and flow of laboratories shutting downa and starting up have helped the market gain customers awareness. Those reseachers that discover they can sell their used products to resellers are more likely to return to them as customers, helping to build a loyal customer base. Used laboratory equipent is an estimated $2 billion market globally and is expected to experience double-digit growth in 2010 following a 2009 plummet due to the extreme economic recession. With the awareness of refurbished and used equipment options growing, the market is expected to maintain healthy growth over the next five years.

Business Dynamics:
The used equipment market relies on differant types of researchers to stock its inventory and purchase products. Most used equipment suppliers boast savings of 40-75 percent off new product prices, so they market to budget conscientious researchers as customers. To acquire inventory, vendors depend of laboratories shutting down or researchers upgrading to the latest technology. For instruments whose technology changes quickly, on to five years old is the best range for reselling. This category includes high-end analytical instruments, such as sequencers, mass spectrometers, and various kinds of microscopes, to name a few. To obtain these types of products for resell, suppliers often reply on early adopters to quickly buy teh newest technology and liquidate their older instruments. These older instruments may not contain the cutting-edge technology or novel features, but they continue to be functional for laboratories that do not necessarily need or caonnot afford the latest product. For more basic equipment or laboratory furniture with little recent technology development, used providers sell products older than five years old. This category includes products such as hoods, shakers, freezers and other low-cost or non-analytical equipment. These types of products cater to a customer base content with reliable, practical, workhorse equipment.

In an economic recession, these standard business dynamics change. In a light to moderate recession, markets targeted toward cost-conscientious end-users tend to benefit and even increase growth, as consumers seek better value in used products. Furthermore, under these conditions, new product vendors often keep prices flat or raise them slightly to accommodate lower sales volume. This maintains the significant pricing differance between new and used laboratory products necessary for end-users to see the value in buying used. However, in extreme economic recessions, like the recent one that began in fall 2008, manufacturers are more likely to drop prices and reduce the difference between new and used products to 20-40 percent. This decreases the value of buying used products. Furthermore, those researchers with sufficient budgets to purchase instruments during an extreme recession likely do not fit into the budget conscientious typecast of used equipment market in 2009. Nevertheless, the market has rebounded in 2010 due in part to the return of normal new product pricing and the restoration of more generous spending following a tight-pocketed year and a half.

Increasing Competition:
The business model of laboratory equipment resellers makes it an attractive market for new entries. Competitors now include the likes of EquipNet, Bid-Service, Harlow Scientific, LabX and many others. This market is expected to grow in the number of competitors over the next several years, as several factors contribute to a simple entry process. The company does not need manufacturing capabilities, keeping spending on labor and facilities extremely low. Furthermore, the trend of consolidation among pharmaceutical, biotechnology, diagnostics, and life sciences companies continues to reduce the number of laboratories, as mergers often necessitate triaging vital R&D from superfluous or duplicate labs. As laboratories close down, this creates a surplus of equipment that can either collect dust in storage, or more intelligently, can be sold to a reseller for cash. Therefore, once a startup reseller gains brand awareness, the trend of consolidation will help make the accumulation of used equipment straightforward. Companies that offer fully refurbished instruments suchs as Harlow Scientific, collect this used equipment, recondition it through qualified service technicians, and resell them with warranties. Other vendors sell used instruments "as is", without conducting any services.

Still other vendors choose to take a lesser role in the reselling process, only serving as a means for buyers and sellers to connect. Vendors such as LabX serve as Internet marketplaces for laboratory products, but do not buy or sell any of the equipment that changes hands. These companies function as auction sites reminiscent of the eBay business model and/or posting sites similar to newspaper classifieds sections. These companies generate a portion of their revenue by charging sellers for posting ads. This hands-off approach creates a rapid and inexpensive startup process, allowing for easy entry into the market. We expect several new vendors of this kind to enter the market over the next few years.

Industry Relationships:
As the market for used laboratory equipment grows, in terms of competitors, customers, and revenue, new product vendors are still fumbling with how to react. Some companies have take the approach, "if you can't beat them, join them." Thusm new product vendors are starting to partner with resellers to offer new and demo equipment, often at reduced prices. When new product sales are slow and inventory stocks up, resellers provide a simple option for liquidation. Despite these positive relationships, other new equipment manufacturers continue to view used product vendors as competition and throw roadblocks in their way. Manufacturers may refuse to sell instrument parts, so used vendors cannot refurbish the used equipment. Others simply want to keep their competitors' old equipment off the market and take competitors' instruments as trade-ins when customers upgrade and dispose of them. Used laboratory vendors hope this mindset changes, as they view their recycling efforts as green-minded. Ultimately, the relationship between new and used vendors continues to evolve, and time will tell if new manufacturers begin to see the benefits of partnership.

Conclusion:
While the used laboratory equipment market has existed for decades in various forms, it has more recently emerged with a much larger presence in the life science tools market. With customer awareness and acceptance growing, the market is expected to maintain strong growth over the next several years. Furthermore, with attractive, simple business model options, competition is likely to increase with new companies finding few entry barriers. With such an outlook, new product vendors should find ways to take advantage of the trend, rather than fight it.

Harlow Scientific, a privately-held company based in Arlington, Mass... purchases, refurbishes and resells pre-owned scientific laboratory equipment. This unique company, founded in 2007 by Justin Frey, provides reliable refurbished laboratory instruments, furnishsing and surplus consumables at affordable prices.

Harlow differentiates itself from other used equipment companies by providing top quality products that are refurbished by qualified technicians, rather than resellting instruments is "as is" condition. The company provides its standard six month warranty on all parts and workmanship, and can arrange to service a broad range of technology for its customers. These practices assure customers that their Harlow purchases will function properly and are well worth their investment. Harlow is diligent about earning the trust of its customers and prides itself on maintaining a stellar relationship with the scientific community. Harlow's Commitment to customer satisfaction has contributed to the company's rapid growth and market success.

Harlow's products range from basic laboratory equipment, such as balances and chillers, to very high-end analytical instruments including mass spectrometers, flow cytometers and sequencers. Harlow Scientific sells refurbished products for 40-80 percent less than new models.

In addition to its refurbished business, the company partners with industry manfacturers to sell new and demo products at a 20-60 percent discount. Molecular Devices, Eppendorf, IlShin, Adam Balances, PG Instruments are some of the companies that Harlow collaborates with for this business model. Harlow also offers renting and leasing options, allowing researchers the flexibility to rent instruments for short-term projects. All of these options provide researchers savings and confidence in the reliability of their purchases.

Click Here To Read Full Article:

Eppendorf 5810R | Used Refrigerated Benchtop Centrifuge

The Eppendorf 5810R features a brushless maintenance-free motors. Accommodates a variety of rotors to meet your application needs. They are three centrifuges in one: a high-capacity, general-purpose centrifuge for cell harvesting; a high-speed centrifuge for separating cell lysates; and a microcentrifuge for DNA precipitations.

The refrigerated 5810 R offers maximum application versatility and popular tube capacity, accommodating up to 4 x 400 ml tubes or 16 microplates. These compact, benchtop centrifuges achieve remarkable throughput of up to 48 x 15 ml or 20 x 50 ml conical tubes.


Eppendorf 5810R Includes - 4-Place swinging bucket rotor, buckets, power cord, operator's guide, rotor key and Harlow Scientific warranty.



Contact info@harlowscientific.com for more details.

Rehab In The Lab | Lab Business Magazine Article



Grandma has a problem. She needs eggs to finish baking a birthday cake for her granddaughter. But as she lifts the curtain and looks outside the window, she sees snow on the walk, ice on the road, and she wonders if it’s a good idea to leave the house. She doesn’t want to slip. And it’s very cold. Maybe it’s best to stay inside, she thinks, even though she’s been inside for days.

Such a scenario isn’t uncommon. Mobility is an issue for many seniors and fears about slipping on ice and the dangers of cold weather are a concern for many more. Making life easier and safer is one of the areas of research at the iDAPT Centre for Rehabilitation Research, a $36 million, 65,000 square-foot research lab located at Toronto Rehabilitation Institute. At the core of iDAPT (short for Intelligent Design for Adaptation, Participation, and Technology), are seven simulators that replicate environments as diverse as Toronto’s downtown streetscape, a modest income home, and a hospital room. Geoff Fernie, Vice-President of Research at Toronto Rehab, says that simulation is the basis of the lab’s approach to rehab studies because simulation offers more soundness in research results.

“The thing I’ve found is that there is better research when done with simulations,” says Fernie. “We need objective testing to [draw conclusions],” and simulation is the way to create the most objective—in this case, true-to-life—scenarios possible.

Winter labBut back to Grandma. She’s afraid to leave the house because she might slip. Mobility issues, including a senior’s ability to keep balance, or a stroke patient’s ability to relearn walking, are some of the real-life issues that iDAPT attempts to tackle in the Winter Lab.

From the outside, Winter Lab looks like a big box, almost like a cooler for beer. The outside panels are painted to look like a northern Canadian landscape. Inside the box, the picture changes. The floor is made of a steel mesh lined with pink tubes filled with glycol. A harness system runs along the ceiling and attached to the walls are mounts for motion capture cameras. When iDAPT researchers are ready to run experiments, they fill the floor with water and freeze it, lower the temperature inside the lab to minus 15 C, and if they want to, send a 30 km wind blasting across the landscape. In a few months, the lab will have a snow machine to add to the reality of the scenario.

When the lab is set up, a hoist lifts it into the air and sets it on a motion simulator nested in the floor of the subbasement. Then the real work begins, as scientists place a person in the harness, tilt the lab to any angle, and experiment with mobility issues in winter conditions. It’s the most real winter scenario possible, short of stepping outside in mid-January or flying to Yellowknife, and it’s a lab that iDAPT is using to gain a better understanding of how icy conditions affect a person’s mobility.

Commercializing technology
Inside Winter Lab, iDAPT researchers are working with a shoe company to design a better winter shoe. In fact, all of the labs at iDAPT represent opportunities for the commercialization of research. “They are designed to accelerate how we get things from the lab to application,” says Fernie.

Sitting on the floor beside Winter Lab is Stair Lab and Street Lab. Inside Stair Lab is a stair case where researchers test different heights and rises of stairs with the hopes of creating staircase standards that will help reduce the number of falls experienced on stairs. Inside Street Lab is a virtual reality simulation of the streets outside of Toronto Rehab, complete with everything from newsstands to city monuments, the rumble of passing streetcars to the noise of birds and pedestrian signals, all of it in stereo sound. Researchers use Street Lab to understand how stroke patients regain the ability to walk and to test functionalities of a new kind of hearing aid.

Click Here To Read Full Article:

Qiagen PSQ HS96A | Biotage Pyro Sequencer

Qiagen (Biotage) PSQ HS96A High Throughput Pryo Sequencer For Sale. Instrument is in excellent condition and service by the manufacturer with service records.

The Qiagen PSQ HS96A includes - Brand New Vacuum Station, Brand New Licensed Software, Brand New Pentium IV Data Station, Brand New LCD Monitor, Qiagen PM & Calibration Prior To Shipment, Qiagen Service/Calibration Documents, Operator's Guide, All Required Cables, Guaranteed To Meet Factory Specification, Harlow Scientific Warranty. This instrument is ideal for labs looking to do SNP analysis, Methylation experiments, or sequence analysis.

If you would like to receive more information please contact: info@harlowscientific.com

The Lost Decade | Canada's Decline in Clinical Trials | Lab Business Magazine Article

With Canada already one of the least popular places in the world to conduct clinical trials, Canadian labs face significant challenges to bring future trial work home. Canada faces competition from developed economies and developing countries, where the costs of conducting trials is lower, finding patients to volunteer for drug testing is easier, and regulation is simpler.

Lowly rankedCanada’s ranking as a place to conduct clinical trials has dropped steadily over the last five years. Between 2006 and 2010, the number of clinical trials and trial sites in Canada dropped approximately 30 per cent, with clinical trial applications for non-generic drugs decreasing to 596 from 777.

This flight of research from Canada sparked industry, academia and government to gather in Ottawa in September 2011 for the first Canadian Clinical Trial Summit. There, industry and policy-makers discussed Canada’s downward trend and worked on an action plan to improve Canada’s competitiveness.

The issue of Canada’s weakened competitiveness is not a new one. According to an article in the January 2009 Canadian Medical Association Journal, many people involved in clinical trials believed that cost and conflicting requirements were among the causes for the Canadian system’s disarray. In the article, Ronald Heselgrave, chair of the ethics board at the University Health Network, said there is the fear that once clinical trials leave Canada they will be difficult to get back. This fear may be the new reality. Clinical trials continue to decline, and there is little incentive for companies to come to Canada except for a history of excellence in research. “What we’re talking about is a lost decade,” says Jack Corman, President, and Institutional Review Board Services. “So now we’re trying to play catch up.”

Corman says that how Canada proceeds depends on what government wants to accomplish—to rearrange the furniture or to make fundamental change to the clinical trial system in Canada. “Talk is cheap, and it’s not cheap talk. There are millions that have been spent—and I deliberately do not use the term invested—on governments constructing schemes to bring more research [to Canada], to harmonize or centralize ethics reviews in a government run system, and they’ve backfired every time. So maybe this time it’ll work, but I’m not counting on it based on the past record,” says Corman.

Expensive research
Canada is now the most expensive country in the world in which to perform a clinical trial. Although cost is only one of the many factors a company takes into consideration when choosing a clinical trial location, the price to do research in Canada is almost double that of Spain and the United Kingdom. In comparing the per-patient cost for the same trials, Canada is nearly twice as costly as France and Germany.

Click Here To Read Full Article:

Becton Dickinson FACSAria | Used 2006 Cell Sorter


The BD FACSAria was the first benchtop cell sorter that was equipped with a fixed alignment cuvetter flow cell, giving superior fluorescence sensitivity. The fixed optical system makes this reliable tool free of maitenance and alignment. Easy to use FACSDiva software allows you to setup and monitoring sorts with a few mouse clicks. Strean monitoring of the breakoff point and clog detection, giving you the abililty to automate your lab. WALKAWAY TECHNOLOGY.




The BD FACSAria cell sorter sets a new standard for highperformance flow cytometry. Based on an entirely new design in instrumentation, the BD FACSAria instrument is the first benchtop sorter that incorporates a fixed-alignment cuvette flow cell that can detect up to 13 colors, for a total of 15 parameters. The cuvette flow cell allows for up to three aircooled or solid state lasers at 488 nm, 633 nm, and 405 nm. Faster digital electronics allow for acquisition rates of up to 70,000 events per second. High-performance sorting is easy to set up, perform, and monitor with built-in BD FACS™ Accudrop technology and sort monitoring features within the software.

2006 FACSAria Includes -
3 Lasers (Blue, Red, Violet), ACDU option, AMO, chiller, LCD Monitors, HP workstation with FACSDiva 6.1.2 software, manuals, fluidics cart and more. Instrument just received a PM in the beginning of 2012. Don't miss out on this amazing deal.

***This system won't last long***

If you would like to receive a quote, please contact: Joe@harlowscientific.com








Why Not Thorium | Lab Business Magazine Article



When Canadian scientists set out to design nuclear reactors in the early 1950s, they did so with an eye to the future, the far future, when uranium supplies ran out. The Canada Deuterium Uranium (CANDU) reactor, the product of this foresight, can burn thorium as well as uranium. At the time of the initial design, burning thorium, a cleaner burning nuclear fuel, seemed fantastic—the market wanted uranium reactors, and besides, thorium burns so hot that scientists had no technology at the time to actually burn thorium.

Now we do. Robotics can now support the thorium cycle in a commercial environment, giving way to the possibility of a commercial-scale CANDU reactor burning thorium.

Now it seems that thorium’s time—a time Canadian scientists envisioned at the dawn of the nuclear age—has finally come, as China’s growing economy adopts thorium reactors, as countries around the world look more closely at their growing energy needs, at the dangers associated with nuclear power, and the inadequacy of so many renewable energy sources.

The Canadian perspective
In the 1950s, Canadian scientists designed nuclear reactors to use natural uranium, instead of enriched uranium, in an effort to combat nuclear proliferation. “[Canadian labs] designed a technology that worked with natural uranium,” says Dr. Dave Novog, Associate Professor in the Department of Engineering Physics at McMaster University. “This meant we didn’t need enrichment facilities that could be construed as being weapons. In fact, we’re quite far from any technology that would be needed for weapons.”


Canada poured hundreds of thousands of dollars into thorium research in the 1950s and 60s, planning to eventually migrate to a domestic thorium cycle and sell the country’s substantial uranium stores as other countries run dry. Knowing the necessities of a thorium cycle, scientists designed the reactor to one day flourish in a thorium economy.

“The developers always had this thorium cycle in mind,” says Dr. Dan Meneley, former Chief Engineer of Atomic Energy of Canada Limited. “I’d say a fair amount of good management and a whole lot of luck went into those reactors.”

So why use uranium at all?
“Things that happen early on tend to determine which way a country goes with a given technology,” Meneley says. “You can’t run a nuclear reactor without a fissile material and thorium doesn’t come with a fissile material. Without the technology to support thorium in the beginning, our only choice was to use natural uranium in our nuclear reactors, so that’s what we used.”

Thorium becomes uranium 233 in a thorium reactor. Advanced reprocessing at substantial cost is necessary in the thorium-to-uranium conversion.

While they used natural uranium as a fuel source, Canadian scientists developed early CANDU reactors with a thorium agenda. And for good reason. Canada holds about 100,000 tons of thorium according to the World Nuclear Association, outstripped only by India (360,000), Australia (300,000), Norway (170,000), the U.S. (160,000) and possibly China.

The dollar economy
Canada possesses large stores of thorium and the technology to use it, but, like most other nuclear countries, continues to burn uranium for fuel.

“It’s much cheaper to do things the way we do right now,” says Dr. Adriaan Buijs, President of the Canadian Nuclear Society. “We do have large quantities of thorium, but we also have one of the largest reserves of uranium on the planet. At the moment, thorium simply isn’t a priority for us and that’s why we’re not focused on it. In China, it’s a different story.”

According to Buijs, thorium is burning in CANDU reactors in China today. “The reactors we designed are the only type of reactor that can use thorium essentially as they are,” he explains. Canada holds enough uranium to power its nuclear reactors for decades while still exporting to countries like India with rising demand.

For any country to migrate to a thorium cycle, the associated costs must drop. Currently, thorium costs about $5,000 per kilogram compared to uranium 235 at $40. However, the World Nuclear Association projects thorium could drop as low as $10 per kilogram when mined en masse.

A one gigawatt uranium plant costs about $1.1 billion to build and $30 million to fuel annually. The World Nuclear Association says a thorium plant of equal size could cost as little as $250 million and fuelling it might cost $1 million annually.

Experts believe this is the future of energy mass production and it will come when necessity dictates. “For somewhere like Germany or Italy, life is going to be very painful when oil is up to $300 per barrel,” says Meneley. “We can’t count on natural gas and we can’t count on oil. Without nuclear, and thorium as a significant part of that, it will be a low energy future.”

Click Here To Read Full Article:

Molecular Devices SpectraMax M5 | Multilabel Microplate Reader

The SpectraMax M5 Multi-Mode Microplate Reader delivers single-mode reader performance in one multi-mode reader package. The dual monochromator optics allow the widest range of applications to be utilized for bioresearch and drug discovery applications, all without the need to change filters. This robust system as the ability to run in UV/Vis, Fluorescence, Fluorescence Polarization, Time Resolved Fluorescence and Luminescence. Applications include DNA/RNA protein quantification and purify, ELISA/Enzyme Kinetics, cAMP Assays, FRET, Catch Point, Reads Cuvettes and more...


The SpectraMax M5e Micoplate Reader possesses the five modes preferred by the majority of our users providing the benefit of multiple detection modes in one platform.

• UV-Visible Absorbance (Abs)
• Fluorescence Intensity (FI)
• Time-Resolved Fluorescence (TRF) including CisBio HTRT Certification
• Fluorescence Polarization (FP)
• Glow Luminescence (Lumi)

The SpectraMax M5 Microplate Reader is the standard for UV/Visible multi-mode reader absorbance, providing ultrafast, full spectral range detection for cuvettes, 96-well, and 384-well microplates.

For fluorescence intensity, time resolved fluorescence, and fluorescence polarization assays, the SpectraMax M5 Microplate Reader optical design provides the highest level of flexibility. Users can select from top or bottom read modes for improved sensitivity for solution and cell-based assays. Assays can be better optimized by scanning across a range of wavelengths in increments as small as 1 nm. Up to 4 wavelength pairs can be read in one protocol for endpoint and kinetic measurements, allowing for fast setup of FRET and TR-FRET assays, including CisBio's HTRF assay.

The SpectraMax M5 Microplate Reader is supplied with SoftMax Pro Data Acquisition & Analysis Software, Molecular Devices' industry leading all-in-one software. Additionally, the SpectraMax M5 Microplate Reader can be seamlessly integrated with the StakMax Microplate Handling System through SoftMax Pro Data Acquisition & Analysis Software.

If you would like to receive a quote, please contact Joe@harlowscientific.com


Click Here For More Details:

Diving Into Aquatic Life | Lab Business Magazine Article



The resilient red and black fishing boat pitches sharply to the left, then just as aggressively to the right as the waves of the North Atlantic Ocean assail it as though it were an unwelcome guest. The sun shows no sign of breaking through the blackened clouds now occupying the sky as far as the eye can see in all directions. The deck seems submerged. Salty mists and powerful waves dance back and forth across the rubberized surface.

This could easily be a scene out of The Deadliest Catch, and indeed a few days earlier it may have been just that. But today, this crab fishing vessel has a different objective. Today it searches for snow crab not for the purpose of human consumption, but for study. Snow and queen crab are, according to Fisheries and Oceans Canada, a more than $500 million economy in Canada, making these cold-water dwellers the second-largest seafood product by value in the Canadian economy, lagging behind only lobster with a reported value of $803 million in 2009.

This vessel’s job for the week is to ferry a team of field researchers from the aquatic section of the Atlantic Veterinary College (AVC) at the University of Prince Edward Island to a destination where they can collect samples, test them in the field for any of a number of ailments and bring a few back to the wet lab for further investigation. This particular team is looking into bitter crab disease (BCD), led by 25-year veteran of AVC, Dr. Rick Cawthorn, Professor of Parasitology in the Lobster Science Centre.

“Our primary goal with this right now will be to determine whether or not BCD is a significant mortality factor in snow crab populations and how it’s causing disease among these populations,” says Cawthorn. “This will allow fisheries managers to look at BCD in a way that better allows them to manage populations.” Cawthorn also plans to work with colleagues at the UPEI Food Technology Centre to determine the cause of the bitter taste associated with the disease, and methods to remove it. In order to do this, Cawthorn’s field workers transport sample crabs from the field to AVC’s aquatic animal facility. As part of a soon-to-be-completed $45-million expansion and renovation project, AVC is growing its aquatic holding facility by 8,000 square-feet, with the new addition expected to open in 2011.

“Our expanded aquatics holding facility is an important step forward in achieving our goal of becoming the world’s leading academic-based aquatics health institution,” says Dr. Jeff Wichtel, Associate Dean of Research. The aquatic facility contains a series of standalone salt-water recirculation units. Salt-water is necessary because the majority of subjects studied here are ocean dwellers, which presented a problem when building the facility in 1985. “We’re not close enough to the ocean to get salt water pumped in to our facility,” says Wichtel. Economically, building a pipeline to the ocean and maintaining water quality, disinfection and temperature control from that source didn’t make sense. Salt-water wells exist in the area, but not necessarily with the degree of salinity needed to maintain living samples. “Our salt water is made from a package that you basically dump into the water,” says Cawthorn. Substantial fresh water wells provide all the water needed and allow for precise control of the salinity in the interior tanks.

“Our crabs, for example, are held at salinity of 34 parts per thousand,” Cawthorn explains. “The facility people do regular water quality testing and we work closely with them because they’re taking care of our animals and aquarium systems, really the most important part of our work here.” Taking care of the animals also means maintaining precise temperature control. One recirculation unit, for example, may contain crabs that must be held at a temperature of 0 C. Lobsters would be housed in a different unit, with their optimal temperature sitting between 1 C and 10 C. Lobsters are also a significant research focus at AVC and the Lobster Science Centre (LSC) is the only lobster research centre in the world that is part of a veterinary college. In 2000, scientists at LSC pioneered a new, humane method of euthanizing lobsters for study. Dr. Andrea Battison observed lobsters under imaging ultrasound and ended the use of pesticide baths in euthanizing the animals by introducing an injection that stops the heart very quickly.

Studying animals such as snow crab, lobsters and shrimp will provide critical information allowing this industry to continue to grow, but there are a number of other fisheries critical to the Canadian and global economies in which AVC plays a pivotal role.


Agilent 6890 5973 | GCMS Refurbished System

Description - The Agilent 6890 was designed to replace the ever popular HP 5890 work horse GC. The 6890 and 6890 Plus delivers high levels of performance with electronic pneumatic controls of all gas flow and pressures. Built-in sensors automatically compensate for ambient changes in temperature and barometric pressure differances to reach more accurate and reproducible results. The EPC control gives stable results and reduces your need to recalibrate, giving your lab more productivity. The Agilent 6890 systems can be configured in a number of differant ways to meet your analytical or R&D labs needs.





Key Areas of Study -
• Chemical Analysis
• Food Safety
• Forensics
• Drug Screening
• Toxicology
• Biodiesel
• Environmental
• Research Labs (R&D)
• Analytical Labs (contract labs as well would benefit from the 6890/5973)
• Pesticide Analysis
• Hydrocarbon Processing

Includes -
Agilent 6890 Gas Chromatograph, Agilent 5973 MSD with EI and CI, Agilent 7683 Auto-injector and Sample Tray, Pentium IV Data Station, Chemstation Software, Split/Splitless, New Column, Power Cord, Vacuum Pump, Operator's Guide, Harlow Scientific Warranty. * Starter Kit Sold Seperately*


If you would like to receive a quote, please contact: Joe@harlowscientific.com


Click Here For More Details:

One Lab's Trash is Another Lab's Treasure | Lab Business Magazine Article

For many laboratories, funding is very rarely abundant. Lab managers must often make decisions concerning which equipment must be replaced and which will need to be strecthed for another year, possibly placing limitations on lab productivity. Consider stretching your lab's budget significantly further this year by investigating whether or not the equipment needed in next year;s upgrades can be purchased second-hand. You'll not only be saving money, but also the environment.

"Right now, I'm going through a sale with a piece of equipment called a LEADseeker, which is a product from General Electric," says Chris Ayotte, Director of Operations and equipment re-seller at Harlow Scientific. "To buy this piece of equipment new, a lab would be looking at a price around $200,000. We, on the other hand, are making this deal for $85,000.00. We got this at a good deal ourselves and have been able to pass those savings on to a good client of ours."

Harlow Scientific buys, sells, rents and stores gently used scientific equipment, a niche of the lab industry that has grown increasingly appealing over the last few years. "There is an obvious answer as to why people are looking to this option" says Ayotte. "People want to save money."


Recently, Kristina MacNaughton, a research technician at the University of Alberta, needed to make the most of her money. "I was working for a brand new investigator, and when he got here, he was applying for grants. Our institution gives a bit of a startup fund to get equipment for the lab, but when you have to buy everything from pipettes to large machinery, it gets pricey," she says. The only way to realistically and satisfactorily furnish the new lab was to go second-hand.

Ayotte agrees that for some labs, even saving a few thousand dollars can mean the difference between getting up and running, or not. "We sell an instrument called an M5 from a company called Molecular Devices. We sell a 2008 model like-new for $35,000," Ayotte says. "They are quoting an unused model out for $42,000 to $45,000. People who have the money will shrug off that $7,000 or so and go for the new model, but for a smaller lab, $7,000 is $7,000. For many startup companies or small laboratories, that's still significant. It amounts to money that can be spent on reagents or other stock."

Click Here To Read Full Article:

Tuesday, April 3, 2012

Roche 454 FLx w/Titanium Upgrade | NGS Sequencer




Description - The 454 FLX Genome Sequencer is a high-throughput analyzer, capable of running more than one million high-quality reads per run and read lengths of 400 bases. This system handles a long list of studies such as, de novo sequencing of whole genomes and transcriptomes of any size, metagenomic characterization of complex samples, resequencing assays and more. The 454 FLX uses the titanium reagents and features advanced long reads, brilliant accuracy and high throughput. "Reduce your cost and increase your productivity".









Key Applications -
• SNP Discovery
• Structural Analysis Variation Analysis
• DNA Sequencing
• Cytogenetic Analysis
• Gene Regulation
• DNA Protein Interaction
• RNA Discovery
• Methylation Analysis

Includes - Roche 454 FLX Titanium instrument, Pentium IV data collection station, brand new 19" ACER LCD monitor, Software Suite (GS De Novo Assembler, GS Reference Mapper, GS Amplicon Varient Analyzer), All Required Cables, Service History Report, Installation and six month parts and labor warranty (installation & warranty valid for customers in US and Canada).

If you would like to receive a quote, please contact: Joe@harlowscientific.com


Scientific Talent War | Lab Manager Magazine Article

These are nervous times in laboratories. Staff shortages abound and the workforce is aging, but the recession acts as a defibrillator keeping the laboratory heartbeat humming as veterans postpone retirement. Acting to stem this shortfall and generate interest in science careers, the U.S. National Academies, to considerable fanfare, earlier rolled out a study calling for educational and policy reforms to ramp up the supply of domestic scientific and engineering talent, entitled “Rising Above the Gathering Storm.”

The storm has broken over America’s laboratories. Vexed by acute personnel shortages, medical labs have mobilized into a full-court press—lobbying and working policy levers to attract and retain talent, promoting their profession, and warning of the impact on quality care. Job vacancy rates exceed 50 percent in some states. New lab staffing models with less rigorous educational requirements are being floated.

“I think we have workforce challenges in front us that cannot be fully mitigated,” says consultant Paul L. Epner, citing demand from an aging population and a concomitant rise in testing that outstrips lab automation measures. Epner, who spent 31 years with Abbott Laboratories, helped create Abbott’s Labs Are Vital™ program to address the profession’s lack of public awareness, particularly the students it aspires to attract, most of whom are unaware that the profession is a career option.

Nearly 60 percent of the more than $4 trillion spent on global health care annually supports the clinical workforce, according to management consulting firm McKinsey & Company, and ASCP, like other groups, is pulling out all the stops to raise the profession’s visibility. Labs Are Vital “was not just about selling the profession to non-laboratorians,” says Epner, “but also about boosting a grassroots effort of lab professionals toward their own profession to improve self-esteem.” ASCP, ASCOF, COMA, AACC and APHL all pitched, says Epner, hoping to earn favorable publicity on word of mouth to attract up-and-coming talent. According to a survey by the Coordinating Council for the Clinical Laboratory Workshop—a coalition of about a dozen lab associations— conversations with friends or relatives are far and away the leading mechanism that sparks interest in a lab career.

The demand for true talent always exceeds supply. In a 2007 HR Priorities Survey by ORC Worldwide, nearly two-thirds of respondents identified talent management as their most urgent strategic issue. They have not been disappointed. With waves of workers at retirement age in industrialized nations, and increased competition from developing nations, it’s a seller’s market. As the war for talent intensifies, so does the weight on lab managers tasked with stroking high potential stars.

Workers, goes the old adage, don’t quit bad jobs—they quit bad bosses. Nor do they necessarily follow the money. In the great global game to woo and win scientific talent, more employers—most notably medical labs— are extending noncash motivators as the proverbial carrot. Attracting and retaining talent without pay increases is STAFING“absolutely” a discussion people are having, says Kathy Doig, associate dean at Michigan State University and a national leader in medical lab workforce issues.

Click Here To Read Full Article:

AKTA Explorer 100 | Refurbished FPLC System

Description - The AKTA Explorer is the industry leading FPLC on the market to date. Easily create your own methods with the Amersham Unicorn software. Develop and modify your Chromatography methods within seconds. Flexible system combines reliability and precision giving end users the ability to walk away during sample runs. The AKTA Explorer is fully automated with high levels of automation. This system is ideally suited for laboratories with preproduction method assays.The GE AKTA Explorer 100 is capable of flow rates up to 100ml/min and pressures up to 10 MPa. Each Explorer includes the P-900 pump, UV-900 Monitor, pH/C-900 Monitor, M-925 Mixer, Fraction Collector (Frac-920 or 950), set of valves, operator's guide, Pentium IV data collection system, LCD monitor and warranty.


Fast protein liquid chromatography Definition (FPLC), is a form of liquid chromatography similar to high-performance liquid chromatography that is used to separate or purify proteins from complex mixtures. FPLC system is a complete system for laboratory scale chromatographic separations of proteins and other biomolecules. Liquid Chromatography is a term which refers to all chromatographic method with a liquid mobile phase. The stationary phase may be a liquid or a solid. FPLC is a type of liquid chromatography where the solvent velocity is controlled by pumps to control the constant flow rate of solvents. The solvents are accessed through tubing from an outside reservoir. Depending on the types of separation preferred, various columns are used. FPLC is commonly used in biochemistry and enzymology.



Includes:
AKTA Explorer 100, Detectors, Pump, Pentium IV Unicorn Data Station, LCD Monitor, Manuals, Calibration Report, Harlow Scientific Warranty * Call For Valve Configuration*

If you would like to receive a quote, please contact: Joe@harlowscientific.com




Agilent 1100 (DAD) | Refurbished HPLC System




Description - The Agilent 1100 HPLC modular system is the pace car of Liquid Chromatography systems on the market. The 1100 HPLC modular system allow laboratories to do more with less. Extensive diagnostics with the Chemstation 32 Bit software that also allows for on-site and remote troubleshooting that can identify most failures for speedy repair. Efficient mixing and pulse free solvent delivery from the G1311A Quaternary Pump gives researchers and lab technician quick and accurate results. The Agilent G1315B Diode Array detector uses a deuterium lamp for high intensity and low detection. Each of our HP Agilent 1100 HPLC systems are fully refurbished with OEM parts and come complete with a calibration report. IQ, OQ, and PQ qualifications are available for an additional cost.






Includes - Agilent G1315B Diode Array Detector, G1311 Quaternary Pump, G1316A Colcom (Thermostatted Column Compartment), G1322A Vaccum Degasser, G1313A Autosampler, Pentium IV Computer Workstation, Chemstation 32 Bit Software, 17" LCD Monitor, All Required Cables, Calibration Report, Operator's Guide and our standard parts and labor warranty.


If you would like to receive a quote, please contact: Joe@harlowscientific.com

Click Here For More Details:

To Own or Not To Own | Lab Manager Magazine Article

With the current tough economy, leasing laboratory equipment could be the way to go for many labs that must now work with very tight budgets. Though leasing does carry some risk, it also has many advantages.

“An equipment lease is one of the best ways for businesses to stay ahead of the development curve,” said account specialist Brad Harmon of First Star Capital (Walnut Creek, CA), an independent direct lender whose focus is equipment leasing, including lab instruments.

He added that leasing allows laboratories to use the most up-to-date technology without having to fork over the huge initial amount of capital necessary to purchase the instruments.

“Running a lab entails making sound financial decisions that improve the condition, quality and overall competitiveness of the business as a whole,” he said, adding that leasing offers a number of other advantages, including:

• Flexibility with terms and equipment
• Conservation of working capital and credit lines
• Increased opportunities from not tying up working capital resources
• Tax benefits, such as enhanced depreciation/accelerated write-offs
• Improved financial ratios (balance sheet) with operating expense vs. liability
• Fast turnaround time compared to other forms of financing
• 100% financing typically available for established companies

As with any type of lease, however, laboratory equipment leasing does have its risks and disadvantages.

What you should be aware of
Mike Bartlett, director of global financial services at Thermo Fisher Scientific (Waltham, MA), which has its own leasing program, says there are two main risks in leasing laboratory equipment. The first is that interest rates could change after a customer has signed a lease.

Since Thermo Fisher’s leases are at a fixed rate for the life of the lease, a customer could end up paying more than necessary if interest rates drop during the term of the lease. On the other hand, Mr. Bartlett added, if interest rates rise during the lease term, the customer ends up getting a better deal with the cheaper rate they locked into at the beginning of the lease.

The second risk with leasing is that a customer could commit to the wrong type of lease, he said, meaning it’s definitely worth your while to research the various types of leases before committing. For example, a customer might sign a five-year lease-to own agreement, where they’ll end up owning the instrument after five years, but the technology changes two years into the agreement.

“They’ve decided they’d like to have the latest and greatest technology, but they’re locked into ownership of [an older model of] that particular instrument,” Mr. Bartlett said. Thermo Fisher does a number of things to prevent customers from choosing a lease that may not be the best fit for their company

“We counteract that through different types of structures,” Mr. Bartlett said. “We have operating leases, and we have technology refresh-type offerings that are certainly available for most instruments that we sell. We try and work very closely with the customers if they do decide that they want to upgrade to that [newer] technology.”

Mr. Harmon of First Star Capital added that acquiring laboratory equipment always involves risks—such as acquiring an instrument that is inadequate or inappropriate for the lab’s needs—no matter how that equipment is funded.

“Investing in lab equipment can entail risks, all of which will be prevalent regardless of whether the equipment is leased, purchased outright with cash or acquired with any other funding option,” he said.

He suggested that lab managers who are considering leasing equipment should first think about why the equipment is needed and what the economic justification is. “If the equipment will pay for itself through cost savings/ efficiencies or by creating an additional revenue stream, it will likely strengthen the case for approval,” Mr. Harmon said.

Lab managers should also make sure they have all the relevant credit and financial information organized and ready to submit along with their application for lease approval and have at least an approximate monthly budget in mind, he said. “This [having a monthly budget handy] will allow the lesser to try and put forth the most affordable lease structure (term, payment, etc.),” Mr. Harmon said.

Click Here To Read Full Article: